Dissecting the mammalian synaptonemal complex using targeted mutations
نویسندگان
چکیده
منابع مشابه
Dissecting a population genome for targeted screening of disease mutations.
Compared to mixed populations, population isolates such as Finland show distinct differences in the prevalence of disease mutations. However, little information exists of the differences on the prevalence of different disease alleles in regional populations with different history of multiple bottlenecks. We constructed a DNA-array and monitored the prevalence of 31 rare and common disease mutat...
متن کاملEpigenetics of the Synaptonemal Complex
Meiosis is a process composed of two divisions of the germ line cells without an intervenient S phase, thus there is no duplication of DNA between the first and the second meiotic divisions. The first meiotic division begins with the pre-leptotene that is the stage where the DNA replicates and chromosomes prepare to enter the meiotic prophase I in most of the organisms with sexual reproduction ...
متن کاملMammalian protein SCP1 forms synaptonemal complex-like structures in the absence of meiotic chromosomes.
Synaptonemal complexes (SCs) are evolutionary conserved, meiosis-specific structures that play a central role in synapsis of homologous chromosomes, chiasmata distribution, and chromosome segregation. However, it is still for the most part unclear how SCs do assemble during meiotic prophase. Major components of mammalian SCs are the meiosis-specific proteins SCP1, 2, and 3. To investigate the r...
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The onion species AUium amplectans includes both a triploid and a tetraploid variety. By light microscopy both varieties appear to have normal synapsis during pachytene of meiosis. However, the triploid does not form chiasmata and exhibits almost total asynapsis following pachytene. The tetraploid forms at least one chiasma per homologue and retains pairing through metaphase I. Electron-microsc...
متن کاملHeterochromatin, the synaptonemal complex and crossing over.
A combined light- and electron-microscopic examination of chromosomes from two angiospermous plants, Plantago ovata and Lycopersicon esculentum, and a mammal, Mus musculus, was performed. From this investigation three observations have been made that may be relevant to the observed lack of crossing over in heterochromatin. (1) Differential staining indicates that heterochromatin represents a sm...
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ژورنال
عنوان ژورنال: Chromosome Research
سال: 2007
ISSN: 0967-3849,1573-6849
DOI: 10.1007/s10577-007-1142-1